AIDS cholangiopathy is a biliary syndrome in patients with AIDS. This entity is diagnosed on the basis of clinical features, raised alkaline phosphatase, evidence. AIDS cholangiopathy is a well-documented biliary syndrome in severely immunocompromised AIDS patients[9]. It occurs when strictures in the. As it was suspected that the patient suffered from AIDS cholangiopathy, further laboratory studies were obtained. A stool study for Isospora ova.

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Epidemiology, determinants, and management of AIDS cholangiopathy: A review

With CD4 counts less than cells per cubic mm, associated infections are viral, protozoan or fungal, or caused by Mycobacterium alds intracellulare [ 10 ]. Microsporidia infection in patients with the human immunodeficiency virus and unexplained cholangitis.

The characteristic finding on biopsy in AIDS cholangiopathy is prominent mucosal folds which indicate inflammation and edema.

Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo. Being cost-effective, sonography is an ideal screening imaging modality in an HIV-infected patient suspected to have hepatobiliary pathology. While it is linked to advanced immunosuppression in AIDS patients, particularly in those with extremely low CD4 counts and opportunistic infections, as well as those with drug-resistant HIV infection, it is also seen in developing countries due to less available anti-retroviral therapy, decreased awareness, and medication non-compliance.

The visualized portion of the abdomen showed dilatation of the common bile and pancreatic ducts. Cryptosporidium and Giardia in Africa: According to observational cohort studies published by the D. In approximately one-fourth of patients, the presentation of AIDS cholangiopathy is subtle and not associated with any biochemical abnormalities despite the evidence of cholangiographic abnormalities on imaging studies[ 3536 ].


It has been well established that HIV directly cholnagiopathy hepatocytes, Kupffer cells, and endothelial cells[ 6 ].

When there is involvement of the cholangiopathj ducts, Cryptosporidium and CMV infection are more likely than when the intrahepatic ducts are not involved [ 10 ]. Biliary tract obstruction in the acquired immunodeficiency syndrome. Nausea and vomiting are not uncommon [ 22 ].

Ursodeoxycholic acid has a limited benefit in patients with sclerosing cholangitis and cholestasis. Disseminated histoplasmosis presenting as AIDS cholangiopathy.

It has been proposed that HIV and C. Human immunodeficiency virus HIV is a global pandemic and it has been estimated that 37 million people are infected with it worldwide.

International Journal of Hepatology

Current therapeutic approaches to cryptosporidiosis in immunocompromised patients. The last category involves worsening of co-infection with hepatitis B and C viruses, encompassing accelerated liver damage and progression of fibrosis. The two most commonly detected pathogens are Cryptosporidium and cytomegalovirus CMV. February 1, Article in press: In two-thirds of cases, papillary stenosis is present either alone or in combination with intrahepatic ductal dilatation and multifocal intrahepatic biliary strictures with alternating normal segments, or saccular dilatations.

AIDS patients with CD4 counts less than 50 per cubic millimeter were more likely to have biliary symptoms and an increased risk of death at one year [ 13 ]. Histologically, the polypoid defects correlate with the presence of granulation tissue and do not affect Prognosis [ 16 ]. AIDS-associated cholangiopathy is a form of biliary tract inflammation with stricture formation seen in AIDS patients who are severely immunosuppressed.


It is no longer common in countries in which HAART therapy is widely employed but is still seen in underdeveloped countries. Radionuclide hepatobiliary scanning HIDA can detect duct dilatation but has been supplanted by other imaging modalities. Though albendazole has been cholangioptahy with some success in disseminated Enterocytozoon intestinalis infection including cholangitis, the therapeutic effect seems to be transient[ 49 ].

It is characteristically sharp in nature and may radiate to the back. Alkaline phosphatase elevation may be the sole laboratory abnormality in some patients. It may be a useful in patients suspected of having acute cholecystitis. Alkaline phosphatase levels continue to rise as intrahepatic bile duct sclerosis progresses [ 20 ].

AIDS Cholangiopathy.

However, the visualized portion of the abdomen showed dilatation of the common bile and pancreatic ducts. Though experience is limited, there have been reports of successful biliary stent use in patients with both long and proximal strictures[ 57 ].

The mechanism by which C. Meanwhile, it is still a problem in developing countries due to poor access to HAART, decreased awareness about the disease, and cholanigopathy non-compliance[ 18 ].

Ma YJ L- Editor: The bilirubin and prothrombin time were normal.