We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.

Author: Dalmaran Faele
Country: Qatar
Language: English (Spanish)
Genre: Marketing
Published (Last): 5 June 2005
Pages: 62
PDF File Size: 13.44 Mb
ePub File Size: 13.11 Mb
ISBN: 235-7-82981-225-3
Downloads: 23171
Price: Free* [*Free Regsitration Required]
Uploader: Telabar

PCR products underwent electrophoresis in 1. We report the first outbreak of disease caused by an unusual fungal pathogen, A. It is unknown whether ongoing hospital construction may have contributed to this cluster of cases. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported.

Masson, p, Sterigmatocystis usta Bainier Aspergillus minutus Abbott Aspergillus ustus var. An attack rate was estimated among the potentially exposed HSCT patients using as the denominator the number of patients who were admitted for HSCT from July through October and March through Septemberthe at-risk periods when cases occurred.

Environmental Sampling Based on the spot map, environmental air sampling of patient hospital rooms was performed, and environmental isolates were obtained. The spot map and time line showed that cases clustered mainly along 2 corridors on 2 floors, 1 directly above the other, around the time of diagnosis.


These patients also possessed classic risk factors for IA in that most had graft-versus-host disease that required corticosteroid and other immunosuppressive therapy Curr Infect Dis Rep. Charts were reviewed for clinical data demographics, underlying disease, transplantation characteristics, antifungal therapies, radiographic and laboratory studies, and outcome.

Aspergillus ustus – Wikipedia

The median age of patients was 59 range 29 years; 5 The first occurred from July to October 3 probable lung infections: Filtenborg O 1 Introduction to food-borne fungi. The isolate from patient 3 was not viable on subculturing and, as such, was not available for molecular analysis. On CYA growth medium ustsu 5. J Am Chem Soc. Introduction to Food and Airborne Fungi.

The results of molecular analyses suggest genetic similarity of isolates recovered from patients. Of note, construction of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December The growth of the species basidifies the medium final pH 8.

No changes in laboratory processing or mold identification methods occurred during the study. The hospital is a large tertiary care facility that houses patients with HSCT on the aspetgillus 2 floors the northeast wings of the seventh and eighth floors. Multilobar pneumonia, thyroid, lung, kidney, peritoneum abscesses.

We identified 2 clusters of A.

Aspergillus ustus

Pulmonary infiltrates and erythematous papular skin lesions. A combination of factors, including severity of underlying host immunosuppression and common source acquisition, likely played a role in the reported outbreaks. The highest overall attack rate in HSCT patients was 1.


The fungus is thought to spread through air and water, and be passed on surfaces where spores settle. Based on the clustering of cases in space and time and molecular data, common-source acquisition of this unusual drug-resistant species is possible. Although these toxins may be medically important, the quantities of toxin produced in the environment aspergilljs not be significant 28 Aspergillus Fungi described in Most of these infections were caused by A.

Aspergillus ustus Infections among Transplant Recipients

Patient charts from the four cases were reviewed retrospectively and indicated that postoperative signs of fungal endophthalmitis developed in the patients weeks after surgery. Of note, the lung transplant patient appeared to be colonized with a strain of A. Azzola P Jr, Habicht JM Use of lung resection and voriconazole for successful treatment of invasive pulmonary Aspergillus ustus infection.

Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings [8] including hospitals, [3] [9] soils and bat dung. Support Center Support Center.