FOSPHENYTOIN PACKAGE INSERT PDF

7 DRUG INTERACTIONS. Fosphenytoin is extensively bound to human plasma proteins. Drugs highly bound to albumin could increase the unbound fraction of. Mylan manufactures FOSPHENYTOIN SODIUM Injection in strengths of mg PE in 2ml Vial mg PE in 10 ml Vial. Category: Human Prescription Drug. Fosphenytoin, the long-awaited phosphate ester pro-drug of phenytoin, was developed to overcome many of the .. Cerebyx package insert. Morris Plains, N.J.

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HIGHLIGHTS OF PRESCRIBING INFORMATION

Pro-Epanutin is a prodrug intended for parenteral administration; its active metabolite is phenytoin. If occurs, follow-up observation is indicated and an alternative antiepileptic treatment should be used.

Phenytoin clearance tends to decrease with increasing age [see Clinical Pharmacology Table 9 displays dosing information for seizure treatment or prophylaxis maintenance dose in children. If administration of CEREBYX does not terminate seizures, the use of other anticonvulsants and other appropriate measures should be considered. Products with particulate matter or discoloration should not be used. Additionally, consider alternatives to structurally similar drugs such as carboxamides e.

The modulation of sodium channels may be a primary anticonvulsant mechanism because this property is shared with several other anticonvulsants in addition to phenytoin. Drugs whose efficacy is impaired by phenytoin. Other common manifestations include arthralgias, jaundice, hepatomegaly, leukocytosis, and eosinophilia.

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Fosphenytoin is metabolized to phenytoin, phosphate, and formate. The liver is the site of biotransformation.

In patients with acute hepatotoxicity, fosphenytoin should be immediately discontinued and not re-administered. For the full list of excipients, see section 6.

FOSPHENYTOIN SODIUM Injection mg PE in 2ml Vial mg PE in 10 ml Vial | Mylan

These reactions did not fosphentyoin in severity with repeated administration. Inhibition of phenytoin metabolism may produce significant increases in plasma phenytoin concentrations and increase the risk of phenytoin toxicity. Please refer unsert tables 1 to 10 for examples of dosing, dilution and infusion time calculations.

To view the changes to a medicine you must sign up and log in. Fosphenytoin is a pro-drug of phenytoin and it is rapidly converted into phenytoin mole for mole.

Caution patients against the use of other drugs or alcoholic beverages without first seeking their physician’s advice [see Drug Interactions 7. See Table insetr for infusion times. Fosphenytoin sodium injection is a prodrug intended for parenteral administration; its active metabolite is phenytoin. Boxes of 10 vials with 10 mL solution. Phenytoin sodium equivalents PE: The pharmacological class of the fosphenytoin sodium is hydantoin derivative, and the therapeutic class is anticonvulsant.

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Show table of contents Hide table of contents 1. Fosphenytoin can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome SJSand toxic epidermal necrolysis TENwhich can be fatal. inwert

Anaphylaxis Laboratory Test Abnormality: Total exchange transfusion has been used in the treatment of severe intoxication in children. Metabolism and nutrition disorders.

Dilution Cerebyx ® -fosphenytoin – GlobalRPH

The mechanism of fosphenytoin conversion has not been determined, but phosphatases probably play a major role. There are marked variations among individuals with respect to serum phenytoin concentrations where toxicity occurs. When appropriate, counsel pregnant women and women of childbearing potential about alternative therapeutic options.

Neuromuscular blocking agents Cisatracurium, pancuronium, rocuronium and vecuronium: This occurs within approximately 2 hours after the end of IV infusion and 4 hours after intramuscular IM injection. After opening, any unused product should be discarded. Phenytoin may decrease serum concentrations of T 4.

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